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Pathophysiologic Determinants
LA enlargement is mostly the result of pressure and/or volume overload. LA enlargement due to pressure overload is usually secondary to increased LA afterload in the presence of mitral stenosis or LV dysfunction. The relationship between LA enlargement and increased LV filling pressure has been shown in individuals with25 and without26 mitral valve disease. LA volume overload resulting from mitral valve regurgitation, arteriovenous fistula, left to right shunt, or high cardiac output state can also contribute to LA chamber remodeling.
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